In cycles for unexplained infertility, ovarian stimulation (OS) has been shown to improve outcome in terms of pregnancy rate. Ovarian stimulation protocol is an important factor in determining the success of intra uterine insemination (IUI).
Dr. Abha Majumdar, Director and Head, Centre of IVF and Reproductive Medicine, Sir Ganga Ram Hospital, New Delhi, explains the rationale behind OS in IUI, the drugs used for ovulation induction (OI) in IUI (viz. clomiphene, tamoxifen, letrozole, gonadotrophins), their schedules and various studies showing their use in unexplained infertility. The various OS protocols – anti oestrogens and gonadotrophins for IUI subfertility, problems with OS in IUI, benefits of agonists/antagonists in IUI, role of gonadotropins with or without GnRH analogues in IUI n women with subfertility are discussed.
Dr. Abha Majumdar has been attached to Sir Ganga Ram Hospital since 1987 as consultant obstetrician and gynecologist and presently is ‘Director of Centre of IVF and Human Reproduction’. This centre was developed in the year 1990 to which she has been attached to, since its inception, and has been in the team of doctors responsible for the first IVF baby born in 1991 and the first frozen ooctye baby born in Jan 2009 of Northern India.