The ombophilia is defined as a venous thrombosis with a detectable abnormality in blood. It is important to know a thrombophilic state to prevent recurrence, plan duration of anticoagulation, give prophylaxis in high risk situations and pick up family members at risk.
Eminent haematologist Dr. M.B. Agarwal discusses the pathophysiology and clinical presentation of venous thromboembolism, deep vein thrombosis and pulmonary embolism. The causes, risk factors, tests and the guidelines for testing for thrombophilia are included. It is important to use the right anticoagulant and test at the right time. Antiphospholipid antibody syndrome is an autoimmune disorder characterized by thrombosis, foetal wastage and immune thrombocytopenia. The clinical presentation, laboratory testing of APLA syndrome is discussed at length.
1. Head, Department of Haematology, Bombay Hospital Institute of Medical Sciences, Mumbai
2. Director : Haematology Centre at Ghamat Lodge, 804-A, Dr. B. Ambedkar Road, Dadar TT, Mumbai - 400 014, India
3. Consultant Haematologist
4. Past president : Indian Society of Haematology and Transfusion Medicine 2008-9
5. President : Mumbai Haematology Group, 2008-10
6. Ex-Professor, Division of Haematology, Dept. of Medicine, L.T.M.G. Hospital & L.T.M. Medical College, Sion, Mumbai - 400 022 (Retired)
Present international projects
1)Phase 1 trial : New compound - In patients of multiple myeloma (second relapse) - Piramals
2)Phase 3 trial : Dasatinib vs Imatinib in newly diagnosed patients of chronic myeloid leukaemia - chronic phase (Two arm, open label, randomized trial comparing Dasatinib with Imatinib) - Part of Global trial by BMS
3)Phase IIIB pilot study of efficacy and safety of Anidulafungin in the treatment of candidemia in Asian patients (Part of Global trial by Pfizer)
4)Phase II / III LUCID trial comparing FCR vs FCR + Lumiliximab in relapsed CLL (Part of Global trial by Biogen Idec)